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  • Apr
    24

    BTP Seminar Series: Pratima Cherukuri, Genezen

    McCormick-Chemical and Biological Engineering (ChBE)

    12:00 PM LR4, Technological Institute

    EVENT DETAILS

    Biomanufacturing: Cell and Gene Therapy with a case study on LVV Manufacturing with Producer cell line

    Viral vectors have revolutionized gene delivery for cell and gene therapy over the past two decades. Adeno-associated viruses (AAVs) are widely utilized for in vivo gene replacement and editing, while lentiviral and retroviral vectors (LVVs and RVVs) offer sustained gene expression for cell therapy applications. Despite their efficacy, challenges persist in efficient vector manufacturing, driven by diverse serotypes, capsid variants, and transient transfection methods. Developing a robust and scalable manufacturing process is time-consuming and costly.

    To address these challenges, collaboration with a Contract Development and Manufacturing Organization (CDMO) during the early stages of clinical programs proves beneficial. Genezen, as a leading CDMO, has implemented Tet-off Producer Cell Line (PCL) systems and platform processes to overcome traditional production limitations. For LVVs, our approach consistently achieves high titers exceeding 6e6 IU/mL across multiple productions, demonstrating superior performance compared to traditional methods. The Tet-off PCL system offers enhanced downstream processing, superior residual profiles, and the ability to generate high-titer super lots.

    By eliminating the need for cGMP-grade plasmids, our approach significantly reduces costs and enhances commercial scalability, promising consistent batch yields. This innovation represents a significant advancement in gene and cell therapy manufacturing, potentially improving patient access to therapies based on lentiviral vectors.

    Pratima Cherukuri, with over 15 years of expertise in viral vector process development, analytics, and production, currently serves as the Chief Scientific Officer (CSO) at Genezen, a leading gene and cell therapy Contract Development and Manufacturing Organization (CDMO). Joining Genezen in 2019, she has played a pivotal role in shaping the company's scientific direction. Prior to her role at Genezen, she held a key position at Covance Laboratories, where she led Bioassay development and validation activities. During her tenure at the Indiana University Vector Production Facility, she spearheaded the development of next-generation viral vector processes for Lentiviral and Retroviral vectors. Her responsibilities extended to analytical development and overseeing the delivery of over 15 GMP batches. Pratima has been instrumental in the design of Genezen labs and GMP suites. In her current role, she leads the development of scalable, robust, and economically viable viral vector production processes. Additionally, as the technical sales lead, she collaborates with Genezen commercial teams and clients to ensure scientific and operational excellence, showcasing her commitment to advancing gene and cell therapy technologies. She has a double master’s in biotechnology and is a Cytogenetics major and holds an MBA from Kelley School of Business.

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    TIME Wednesday, April 24, 2024 at 12:00 PM - 2:00 PM

    LOCATION LR4, Technological Institute    map it

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    CONTACT Jennifer Young    jennifer.young@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    1

    BTP Seminar Series: Jorge Vazquez Anderson, Boston Consulting Group

    McCormick-Chemical and Biological Engineering (ChBE)

    4:30 PM

    EVENT DETAILS

    TIME Wednesday, May 1, 2024 at 4:30 PM - 5:30 PM

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    CONTACT Will Chaussee    william.chaussee@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    2

    ChBE Seminar Series: "Interfacial colloidal interactions, dynamics, and assembly: from biomembranes to ordered 2D materials" - Peter Beltramo, University of Massachusetts

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4, Technological Institute

    EVENT DETAILS

    TIME Thursday, May 2, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4, Technological Institute    map it

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    CONTACT Olivia Wise    olivia.wise@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    2

    Thought Leader Dialogue: AI and the Future of Work

    Center for Human-Computer Interaction + Design (HCI+D)

    4:00 PM

    EVENT DETAILSmore info

    TIME Thursday, May 2, 2024 at 4:00 PM - 5:15 PM

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    CONTACT Madison Deyo    Madison.Deyo@northwestern.edu EMAIL

    CALENDAR Center for Human-Computer Interaction + Design (HCI+D)

  • May
    8

    Extending Care: A Conversation about Conservation and Futurity

    Block Museum of Art

    6:00 PM Block Museum of Art, Mary and Leigh

    EVENT DETAILSmore info

    TIME Wednesday, May 8, 2024 at 6:00 PM - 7:30 PM

    LOCATION Block Museum of Art, Mary and Leigh    map it

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    CONTACT Block Museum of Art    block-museum@northwestern.edu EMAIL

    CALENDAR Block Museum of Art

  • May
    9

    ChBE Seminar Series: Influence of visible photons on catalytic reactions at metal nanoparticle surfaces - Phillip Christopher, University of California, Santa Barbara

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4, Technological Institute

    EVENT DETAILS

    TIME Thursday, May 9, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4, Technological Institute    map it

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    CONTACT Olivia Wise    olivia.wise@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    16

    35th Annual Hugh M. Hulburt Memorial Lecture: "Adsorption Thermodynamics for Process Simulation" - Chau-Chyun Chen, Texas Tech University

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4 (M113), Technological Institute

    EVENT DETAILS

    TIME Thursday, May 16, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4 (M113), Technological Institute    map it

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    CONTACT Jennifer Young    jennifer.young@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    23

    ChBE Seminar Series: ARDEI Annual Lecture - "Restructuring the STEM Pipeline: Dismantling Stereotypes and Microaggressions in STEM to Build Networks of Belonging and Support" - Christine Reyna, DePaul University

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4, Technological Institute

    EVENT DETAILS

    TIME Thursday, May 23, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4, Technological Institute    map it

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    CONTACT Olivia Wise    olivia.wise@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    30

    ChBE Seminar Series: Ruihan Li and Kunhuan Liu, Student Seminars

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4, Technological Institute

    EVENT DETAILS

    TIME Thursday, May 30, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4, Technological Institute    map it

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    CONTACT Olivia Wise    olivia.wise@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • Jun
    10

    Northwestern Engineering PhD Hooding and Master's Degree Recognition Ceremony

    McCormick School of Engineering and Applied Science

    9:00 AM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 9:00 AM - 11:00 AM

    LOCATION Welsh-Ryan Arena   

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    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Jun
    10

    Northwestern Engineering Undergraduate Convocation

    McCormick School of Engineering and Applied Science

    2:00 PM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 2:00 PM - 4:00 PM

    LOCATION Welsh-Ryan Arena   

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    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science